What is Tramadol? Tramadol is an authorized medication used to treat mild and severe pain; it can be used alone or with other medicines. The medicine belongs in the family of drugs known as opioid agonists. You can buy Tramadol online as an immediate-release version and extended-release version. The medication should not be used by anyone who is under the age of 12 years. How long does Tramadol stay in your system? The medication can be detected in urine for 1-4 days after consuming the drug, in hair for 6-4 months, in saliva for up to 48 hours, and in blood for about 24-12 hours.