In 2017, a mysterious letter takes Angela to the 1970s and 80s, when a group of daring women operated an underground abortion network known only by its whispered code name: Jane. Dr. Evelyn Taylor-forced to give her baby up for adoption as a teenager– joined the Jane Network to help other women where she crosses paths with Nancy, who becomes a volunteer. Over the years, Evelyn, Nancy, and Angela's lives intertwine to reveal the devastating consequences that come from a lack of choice.